Clomipramine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Clomipramine HCl 是一种血清素转运蛋白 (SERT)。

Clomipramine HCl is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.

Western Blot Analysis Cell Line:Primary cortical neurons Concentration:1 and 5?μM Incubation Time:12, 24 and 48?hours Result:Enhanced the LC3-I conversion to LC3-II in a concentration-dependent manner at all analyzed time points.

Animal Model:C57BL/6?J mice (6 weeks of age and 22 to 25?g).Dosage:20?mg/kg Administration:Treated intraperitoneally for 21 days Result:Both LC3-II and p62 were significantly increased in the liver of Clomipramine treated mice compared to vehicle treated ones.

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Endocrinology/Hormones

5-HT Receptor

5-HT| Sert (Sodium-dependent)| GSTP| Noradrenaline transporter (Sodium-dependent)

Neurological Disease

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17321-77-6

351.31

C19H23ClN2·HCl

>98% (HPLC)

Ethanol: 70 mg/mL (199.25 mM); Water: 70 mg/mL (199.25 mM); DMSO: 70 mg/mL (199.25 mM)

Cl.CN(C)CCCN1C2=CC=CC=C2CCC2=C1C=C(Cl)C=C2

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(-20℃)

With Ice Pack

≥ 2 years